abstract：:Bronchial subepithelial fibrosis is an histological characteristic of asthma. Cytokines and other mediators, such as PDGF-BB, TGF-beta1 and ET-1 found in the asthmatic submucosa can potentially activate a repair process that leads to fibroblast proliferation and collagen synthesis. The mechanisms of modulation of the ...

journal_title：International journal of experimental pathology

authors： Dubé J,Chakir J,Dubé C,Grimard Y,Laviolette M,Boulet LP

更新日期：2000-12-01 00:00:00

abstract：:One of the consequences of neoplastic transformation is deregulation of tissue collagen metabolism. Although metalloproteinases initiate the breakdown of collagen in lung carcinoma, the final step of collagen degradation is mediated by prolidase (E.C.3.4.13.9). We investigated whether prolidase activity could reflect ...

journal_title：International journal of experimental pathology

authors： Karna E,Surazynski A,Palka J

更新日期：2000-10-01 00:00:00

abstract：:Tumour growth is angiogenesis dependent. Thrombosis and thromboembolism are very common in cancer patients. These patients are often treated with heparin as an anti-coagulant. Many tumour angiogens, including VEGF165, and endogenous anti-angiogenesis factors bind heparin tightly. Using the non-surgical mesenteric-wind...

journal_title：International journal of experimental pathology

authors： Norrby K

更新日期：2000-06-01 00:00:00

abstract：:While the origin of tumours, whether from one cell or many, has been a source of fascination for experimental oncologists for some time, in recent years there has been a veritable explosion of information about the clonal architecture of tumours and their antecedents, stimulated, in the main, by the ready accessibilit...

journal_title：International journal of experimental pathology

authors： Garcia SB,Novelli M,Wright NA

更新日期：2000-04-01 00:00:00

abstract：:Interleukin (IL)-6-related cytokines share gp130 as the signal-transducing protein. Cardiac myocytes produce various kinds of cytokines including IL-6 and cardiotrophin-1. Activation of gp130 transduces hypertrophic and cytoprotective signals in cardiac myocytes via JAK/STAT, MAP kinase and PI-3 kinase pathways. Besid...

journal_title：International journal of experimental pathology

authors： Yamauchi-Takihara K,Kishimoto T

更新日期：2000-02-01 00:00:00

abstract：:Cyclophilins are proteins which are remarkably conserved through evolution; moreover they have been found in every possible existing organism, which indicates their fundamental importance. Due to their enzymatic properties, multiplicity, cellular localization and role in protein folding they belong to the group of pro...

journal_title：International journal of experimental pathology

authors： Andreeva L,Heads R,Green CJ

更新日期：1999-12-01 00:00:00

abstract：:The interrelationship between acinar cell apoptosis and tubular complex formation was examined in caerulein-induced pancreatitis using histology, immunohistochemistry, electron microscopy and DNA gel electrophoresis. Rats were given 8 hourly subcutaneous injections of caerulein, 24 micrograms/kg, for up to 2 days. Mor...

journal_title：International journal of experimental pathology

authors： Reid LE,Walker NI

更新日期：1999-08-01 00:00:00

abstract：:The pathogenesis of dengue haemorrhagic fever (DHF) is incompletely understood but it has been suggested that various cytokines may have a role in the process. In this study the profile of the cytokine Transforming Growth Factor-beta 1 (TGF-beta1) was investigated in the sera of 79 patients with various grades of deng...

journal_title：International journal of experimental pathology

authors： Agarwal R,Elbishbishi EA,Chaturvedi UC,Nagar R,Mustafa AS

更新日期：1999-06-01 00:00:00

abstract：:Recently, there have been significant advances toward the development of culture conditions that promote proliferation of primary rodent hepatocytes. There are two major methods for the multiplication of hepatocytes in vitro: one is the use of nicotinamide, the other is the use of a nutrient-rich medium. In the medium...

journal_title：International journal of experimental pathology

authors： Mitaka T

更新日期：1998-12-01 00:00:00

abstract：:In order to clarify the function of hepatocyte growth factor (HGF) in vivo, we have developed transgenic mice expressing HGF in the liver. The bromodeoxyuridine labelling indices in livers from HGF transgenic mice were doubled, compared to those from wild type mice. Livers of HGF transgenic mice expressed high levels ...

journal_title：International journal of experimental pathology

authors： Shiota G,Kawasaki H

更新日期：1998-10-01 00:00:00

abstract：:Blister formation and skin damage can be induced by BaP1, a haemorrhagic metalloproteinase from the venom of the snake Bothrops asper. Pathological changes in the skin were investigated after intramuscular injections of Bothrops asper haemorrhagic metalloproteinase BaP1. Blisters developed within the first hour, with ...

journal_title：International journal of experimental pathology

authors： Rucavado A,Núñez J,Gutiérrez JM

更新日期：1998-08-01 00:00:00

abstract：:Genetically resistant CBA and A/J mice and susceptible BALB/c and C57BL/6 mice were challenged with either an identical infective dose or a minimal lethal dose of Salmonella typhimurium. The histopathological progression of the disease was examined in tissue sections prepared by the JB-4 Plus resin embedding method an...

journal_title：International journal of experimental pathology

authors： Moncure CW,Guo YN,Xu HR,Hsu HS

更新日期：1998-06-01 00:00:00

abstract：:Using uptake of the fluorescent bile acid derivative cholylglycylamido-fluorescein (FITC-GC) as a measurement of liver cell population size and function, the antiproliferative and toxic effects of the well known cytostatic drug, cisplatin was evaluated on rapidly growing rat hepatoma McA-RH7777 cells and rat hepatocyt...

journal_title：International journal of experimental pathology

authors： El-Mir MY,Serrano MA,Macias RI,Dominguez MF,Monte MJ,Marin JJ

更新日期：1998-04-01 00:00:00

abstract：:Ischaemic-reperfusion injury as a model of acute renal failure (ARF) results in increased macromolecular permeability, tubular obstruction, and renal oedema. To investigate the role for coagulation in this model, anticoagulated and saline-pretreated rats were subjected to 60 min unilateral renal artery occlusion (RAO)...

journal_title：International journal of experimental pathology

authors： Druid H,Eneström S,Rammer L

更新日期：1998-02-01 00:00:00

abstract：:A reversible impairment in the ability of the liver to secrete cholephilic compounds has been reported to exist in infant rats born from mothers with surgically induced complete cholestasis during the last third of the pregnancy. Canalicular plasma membranes (CPM) were purified from livers obtained from 4 and 8 week-o...

journal_title：International journal of experimental pathology

authors： Serrano MA,Monte MJ,Martinez-Diez MC,Marin JJ

更新日期：1997-12-01 00:00:00

abstract：:The aim of the present study was to evaluate the coexpression of very early (CD69), early (CD25) and late (HLADR) antigens and to analyse the mean fluorescence intensity (MFI) of such activation markers on synovial fluid (SF) and peripheral blood (PB) lymphocytes of patients affected by rheumatoid arthritis (RA) and o...

journal_title：International journal of experimental pathology

authors： Afeltra A,Galeazzi M,Sebastiani GD,Ferri GM,Caccavo D,Addessi MA,Marcolongo R,Bonomo L

更新日期：1997-10-01 00:00:00

abstract：:We have shown previously that cycloheximide (CHX), a potent protein synthesis inhibitor, induces high levels of apoptosis in Epstein-Barr virus free (EBV(-)) Burkitt's lymphoma (BJA-B) cells, with comparably reduced levels of apoptosis in the EBV positive (EBV(+)) cells. Modulation of CHX-induced apoptosis in EBV(-) a...

journal_title：International journal of experimental pathology

authors： Ishii H,Tamauchi H,Gobe GC

更新日期：1997-06-01 00:00:00

abstract：:The preovulatory follicle provides a unique physiological example of rapid growth accompanied by neovascularization, two processes that are generally characteristic of pathologies such as wound repair or malignancy. During the hours preceding ovulation, follicular growth is accompanied by elevated levels of messenger ...

journal_title：International journal of experimental pathology

authors： Neeman M,Abramovitch R,Schiffenbauer YS,Tempel C

更新日期：1997-04-01 00:00:00

abstract：:Pathological and immunopathological studies were carried out on snake coiled fibres (SCF) which occurred in affected soleus muscle in chloroquine treated rats. The SCF began to appear in denervated soleus muscle by 8 days after chloroquine injection. By day 14, typical SCF were observed with an unusual swirling patter...

journal_title：International journal of experimental pathology

authors： Tsuzuki K,Fukatsu R,Takamaru Y,Yoshida T,Hayashi Y,Kobayashi K,Fujii N,Takahata N

更新日期：1997-02-01 00:00:00

abstract：:The acute phase of experimental Chagas' disease in rats is associated with early lesions of the post-ganglionic sympathetic nerve terminals of the heart, the varicosities being the target. In the superior cervical and stellate ganglia the preganglionic fibres showed no signs of lesion in the course of experimental Cha...

journal_title：International journal of experimental pathology

authors： Camargos ER,Haertel LR,Machado CR

更新日期：1996-06-01 00:00:00

abstract：:Reovirus type 2-induced diabetes-like syndrome in suckling mice is considered to be an animal model for human insulin-dependent diabetes mellitus. We have previously demonstrated that immunopathologic pancreatic islet cell damage might be relevant to reovirus type 2 infection. In this study the involvement of adhesion...

journal_title：International journal of experimental pathology

authors： Hayashi T,Yamamoto S,Onodera T

更新日期：1995-12-01 00:00:00

abstract：:Although the exact mechanism for the progression of myelofibrosis in acute megakaryoblastic leukaemia is unclear, certain humoral factors released from the proliferating megakaryoblasts that are unable to store these factors in their defective alpha-granules, including platelet derived growth factor (PDGF), fibroblast...

journal_title：International journal of experimental pathology

authors： Hassan HT,Hanauske AR,Lux E,Kleine HD,Freund M

更新日期：1995-10-01 00:00:00

abstract：:Regression of submandibular acinar cell hyperplasia after withdrawal of the mitogenic stimulus induced by isoprenaline was studied in male Wistar rats. Intraperitoneal administration of 39 mg of isoprenaline, in divided doses over a 9-day period, resulted in a marked increase in gland size and weight. The proportional...

journal_title：International journal of experimental pathology

authors： Chisholm DM,Adi MM

更新日期：1995-08-01 00:00:00

abstract：:Muramyl dipeptide-Lys(L18) given by daily subcutaneous injection for 14 days induced arthritis in male Lewis, Fischer and nude rats, to a lesser degree in the last two than in the first strain. On the other hand, a single intradermal administration of Freund's complete adjuvant induced arthritis in Lewis and Fischer b...

journal_title：International journal of experimental pathology

authors： Sugawara T,Takada S,Furuhama K,Takayama S,Nomura M,Kato M

更新日期：1995-06-01 00:00:00

abstract：:In this study, viruria following Japanese encephalitis virus (JEV) infection in mice has been shown to appear earlier in pregnant than in normal mice with proteinuria and haematuria. This was related to the production of splenic macrophage derived neutrophil chemotactic factor (MDF) following JEV infection. Intravenou...

journal_title：International journal of experimental pathology

authors： Mathur A,Khanna N,Kulshreshtha R,Maitra SC,Chaturvedi UC

更新日期：1995-04-01 00:00:00

abstract：:Ultraviolet ray B (UV-B) induced dermatitis in the rat may be a model for human psoriasis vulgaris. Detailed studies of this model are reported. Rat skin responded to UV-B irradiation quite differently from human, guinea-pig, or mouse skin. Rat UV-B dermatitis was characterized by a sharply demarcated brownish-red les...

journal_title：International journal of experimental pathology

authors： Nakaguma H,Kambara T,Yamamoto T

更新日期：1995-02-01 00:00:00

abstract：:Administration of 25 mg/kg/day methyl clofenapate to Alpk/APfSD rats for up to 4 days gave rise to hepatomegaly resulting from a combination of hepatocyte hyperplasia, mainly in the periportal region of the lobule, and centrilobular cell hypertrophy. In hepatocytes undergoing mitosis there was a redistribution of dens...

journal_title：International journal of experimental pathology

authors： Soames AR,Foster JR

更新日期：1994-12-01 00:00:00

abstract：:The effect of infection by prototypes from the three major species of Leishmania on the oxidative burst of human mononuclear phagocytes in culture was examined. The presence of intracellular parasites of the three species, L.major, L.donovani and L.mexicana decreased hydrogen peroxide (H2O2) and superoxide anion (O2-)...

journal_title：International journal of experimental pathology

authors： Passwell JH,Shor R,Smolen J,Jaffe CL

更新日期：1994-08-01 00:00:00

abstract：:The formation of new blood vessels, angiogenesis, is an important event in inflammation, wound healing and tumour growth. Mediators produced by various cells when exposed to endotoxin include cytokines (tumour necrosis factor, interleukins 1 and 6, and basic fibroblast growth factor) which, it has been suggested, stim...

journal_title：International journal of experimental pathology

authors： Mattsby-Baltzer I,Jakobsson A,Sörbo J,Norrby K

更新日期：1994-06-01 00:00:00

abstract：:Streptozotocin (SZ)-induced insulitis, which is an animal model for insulin-dependent diabetes mellitus, was suppressed by lactic dehydrogenase virus (LDV) infection. There were no differences in degenerative and necrotic changes of islet cells between SZ-treated mice and SZ-treated mice with LDV infection during the ...

journal_title：International journal of experimental pathology

authors： Hayashi T,Hashimoto S,Kawashima A

更新日期：1994-06-01 00:00:00

abstract：:The original two strains of Mycoplasma genitalium were isolated from the human urogenital tract. No other strains have been isolated from this site since then. We have recently succeeded in propagating a third strain from a urogenital specimen from a patient with urethritis in Vero cell cultures. By electron microscop...

journal_title：International journal of experimental pathology

authors： Jensen JS,Blom J,Lind K

更新日期：1994-04-01 00:00:00

abstract：:Naturally developing spontaneous osteoarthritis (OA) is seen in a number of small animals one of which is the STR/ORT mouse, an accepted model of human OA. A histological evaluation of the patello-femoral joints of 37 male STR/ORT mice has shown features that are inconsistent with the disease in human joints. These in...

journal_title：International journal of experimental pathology

authors： Das-Gupta EP,Lyons TJ,Hoyland JA,Lawton DM,Freemont AJ

更新日期：1993-12-01 00:00:00

abstract：:The effect of dengue type 2 virus (DV) and the cytokines induced by it, on the chemiluminescence (CL) response of mouse spleen cells was studied by luminol-dependent CL. Following intracerebral (i.c.) inoculation of DV, an initial increase in CL response was observed which was followed by a sharp decline from the 4th ...

journal_title：International journal of experimental pathology

authors： Dhawan R,Chaturvedi UC,Mashihi KN,Chaturvedi P,Mukherjee R

更新日期：1993-10-01 00:00:00

abstract：:This study was performed to characterize the intestinal lesions in chronic graft-versus-host disease (GVHD) in mice and to determine a possible role of intestinal intraepithelial lymphocytes (ilEL) in the development of these lesions. Chronic GVHD was induced by transfer of DBA/2 lymphocytes into non-irradiated (C57BL...

journal_title：International journal of experimental pathology

authors： de Geus B,Hogenesch H,de Heer E,Bruijn JA,van den Enden M,Rozing J

更新日期：1993-08-01 00:00:00

abstract：:Up to 40% of children with Reye's syndrome have hypoglycaemia that could contribute to the patient's encephalopathy. We developed a mouse model in which intravenous inoculation of influenza B/Lee virus produced a non-permissive infection of hepatocytes and cerebral endothelial cells and caused many clinical, biochemic...

journal_title：International journal of experimental pathology

authors： Davis LE,Woodfin BM,Tran TQ,Caskey LS,Wallace JM,Scremin OU,Blisard KS

更新日期：1993-06-01 00:00:00

abstract：:Groups of mice were given oestrone acetate or vitamin E subcutaneously to determine how these treatments might modify responses to endotoxic lipopolysaccharide given intraperitoneally. Release of hepatic transaminase and tumour necrosis factor (TNF) into serum and induction of manganous superoxide dismutase in the liv...

journal_title：International journal of experimental pathology

authors： Carbarns NJ,Neale ML,Stark JM

更新日期：1993-06-01 00:00:00

abstract：:During mild (one to two pairs of worms) and prolonged (23 weeks or more) mouse infections with Schistosoma mansoni, but not with S. japonicum, periovular granulomas and fibrosis were seen to be preferentially located along periportal tissues. This caused fibrotic expansion of the portal spaces on a background of norma...

journal_title：International journal of experimental pathology

authors： Andrade ZA,Cheever AW

更新日期：1993-04-01 00:00:00

abstract：:Salivary glands of cat were examined from 1 to 42 days following parasympathectomy and compared with contralateral normal control glands. Microliths were detected by light microscopy in none of 11 parotid, 31 out of 41 submandibular and four out of 22 sublingual glands following parasympathectomy, and one out of 19 pa...

journal_title：International journal of experimental pathology

authors： Triantafyllou A,Harrison JD,Garrett JR

更新日期：1993-02-01 00:00:00

abstract：:Colonization of the genital tract of female mice, mainly BALB/c, by Mycoplasma genitalium, M. pneumoniae and M. pulmonis was enhanced by pretreatment of the mice with progesterone. M. fermentans, M. hominis and M. salivarium, and three serotypes and two untyped strains of Ureaplasma urealyticum colonized under the inf...

journal_title：International journal of experimental pathology

authors： Furr PM,Taylor-Robinson D

更新日期：1993-02-01 00:00:00

abstract：:We determined the feasibility of producing protoporphyric hepatopathy in unrestrained rats by infusing protoporphyrin into their portal circulation via chronic indwelling catheters. Sprague-Dawley rats, 200-300 g, received single (8.5-27.8 mumol) or multiple (64.1-208.7 mumol) infusions of protoporphyrin over 3-240 h....

journal_title：International journal of experimental pathology

authors： Berenson MM,Kimura R,Samowitz W,Bjorkman D

更新日期：1992-10-01 00:00:00